Pathway and Gene-Level Association Test

Pathway and gene level association test using raw data or summary statistics.

CRAN version CRAN RStudio mirror downloads

This R package is used for biological pathway analysis and pathway meta-analysis for genome-wide association studies. This is an enhanced version of ARTP on CRAN. An online application of ARTP2 is hosted at, where data from the 1000 Genomes Project is provided as genotype reference panel.


v0.9.44 (2018-09-11)

  • New options added to generalize a pathway definition. New maintainer for the package.

v0.9.36 (2017-05-25)

  • Since v0.9.26, fix some minor bugs, make some major updates to improve performance, revise help documents, support new R and C++ standards, etc.

v0.9.25 (2016-03-01)

  • Fix a bug in rARTP when none of the SNPs in a gene can pass the data cleaning threshold specified in options. This bug only affects rARTP. Add a new function exclude.snps

v0.9.22 (2016-02-11)

  • Rename the main functions to be rARTP (raw data input), sARTP (summary data input), and warm.start so that it is consistent with our journal paper

v0.9.21 (2016-02-11)

  • First stable submission to CRAN

Reference manual

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0.9.45 by Bill Wheeler, 3 years ago

Report a bug at

Browse source code at

Authors: Han Zhang , Bill Wheeler , Kai Yu , Yifan Yang , R Core Team

Documentation:   PDF Manual  

GPL-2 | GPL-3 license

Imports Formula, parallel, data.table

Depends on stats, utils

Enhances ARTP

System requirements: C++11

See at CRAN