DMR Detection by Non-Homogeneous Hidden Markov Model from Methylation Array Data

Perform differential analysis for methylation array data. Detect differentially methylated regions (DMRs) from array M-values. The core is a Non-homogeneous Hidden Markov Model for estimating spatial correlation and a novel Constrained Gaussian Mixture Model for modeling the M-value pairs of each individual locus.


Reference manual

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1.1.1 by Linghao SHEN, 4 days ago

Browse source code at

Authors: Linghao SHEN <>

Documentation:   PDF Manual  

GPL license

Depends on MCMCpack, mvtnorm, ellipse

See at CRAN