Group Sequential Design for Historical Control Trial with Survival Outcome

It provides functions to design historical controlled trials with survival outcome by group sequential method. The options for interim look boundaries are efficacy only, efficacy & futility or futility only. It also provides the function to monitor the trial for any unplanned look. The package is based on Jianrong Wu, Xiaoping Xiong (2016) and Jianrong Wu, Yimei Li (2020) .


Reference manual

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install.packages("HCTDesign")

0.7.4 by Tushar Patni, a year ago


Browse source code at https://github.com/cran/HCTDesign


Authors: Tushar Patni [aut, cre] , Yimei Li [aut] , Jianrong Wu [aut]


Documentation:   PDF Manual  


GPL-3 license


Imports Rdpack, diversitree, mvtnorm, flexsurv, stats, survival, crayon


See at CRAN