The Hybrid design is a combination of model-assisted design (e.g., the modified
Toxicity Probability Interval design) with dose-toxicity model-based design for
phase I dose-finding studies. The hybrid design controls the overdosing
toxicity well and leads to a recommended dose closer to the true maximum tolerated
dose (MTD) due to its ability to calibrate for an intermediate dose. More details
can be found in Liao et al. 2022