Subtracting Summary Statistics of One or more Cohorts from Meta-GWAS Results

If results from a meta-GWAS are used for validation in one of the cohorts that was included in the meta-analysis, this will yield biased (i.e. too optimistic) results. The validation cohort needs to be independent from the meta-GWAS results. MetaSubtract will subtract the results of the respective cohort from the meta-GWAS results analytically without having to redo the meta-GWAS analysis using the leave-one-out methodology. It can handle different meta-analyses methods and takes into account if single or double genomic control correction was applied to the original meta-analysis. It can be used for whole GWAS, but also for a limited set of SNPs or other genetic markers.


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install.packages("MetaSubtract")

1.1 by Ilja M. Nolte, 9 days ago


Browse source code at https://github.com/cran/MetaSubtract


Authors: Ilja M. Nolte


Documentation:   PDF Manual  


GPL (>= 3) license



See at CRAN