The provided benchmark suite enables the automated evaluation and comparison of any existing and novel indirect method for reference interval ('RI') estimation in a systematic way.
Indirect methods take routine measurements of diagnostic tests, containing pathological and non-pathological samples as input and use sophisticated
statistical methods to derive a model describing the distribution of the non-pathological samples, which can then be
used to derive reference intervals. The benchmark suite contains 5,760 simulated test sets with varying difficulty.
To include any indirect method, a custom wrapper function needs to be provided.
The package offers functions for generating the test sets, executing the indirect method and evaluating the results.
See ?RIbench or vignette("RIbench_package") for a more comprehensive description of the features.
A detailed description and application is described in Ammer T., Schuetzenmeister A., Prokosch H.-U., Zierk J., Rank C.M., Rauh M. "RIbench: A Proposed Benchmark for the Standardized Evaluation of Indirect Methods for Reference Interval Estimation". Clinical Chemistry (2022)