Graphical Approach Optimal Sample Size

Graphical approach provides a useful framework for multiplicity adjustment in clinical trials with multiple endpoints. This package includes statistical methods to optimize sample size over initial weight and transition probability in a graphical approach under a common setting, which is to use marginal power for each endpoint in a trial design. See Zhang, F. and Gou, J. (2023). Sample size optimization for clinical trials using graphical approaches for multiplicity adjustment, Technical Report.


Reference manual

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install.packages("graposas")

1.0.0 by Jiangtao Gou, 3 years ago


Browse source code at https://github.com/cran/graposas


Authors: Jiangtao Gou [aut, cre] , Fengqing (Zoe) Zhang [aut]


Documentation:   PDF Manual  


GPL-3 license


Imports GA, graphics, mvtnorm, stats


See at CRAN