Gene-Level Variant Association Tests for Pedigree Data

Gene-level variant association tests with disease status for pedigree data: kernel and burden association statistics.

rpedgene (pedgene on CRAN)

Gene-level kernel and burden association tests of genetic variants with a trait of interest, allowing for related individuals, including twins.

Authors

Daniel J. Schaid and Jason P. Sinnwell Small contribution by A. Visconti

Manuscript:

Schaid DJ, McDonnell SK., Sinnwell JP, Thibodeau SN. (2013) Multiple Genetic Variant Association Testing by Collapsing and Kernel Methods With Pedigree or Population Structured Data Genet Epidemiol, 37(5):409-18