Utilities and Design Aids for Up-and-Down Dose-Finding Studies

Up-and-Down (UD) is the most popular design approach for dose-finding, but it has been severely under-served by the statistical and computing communities. This is the first package that comprehensively addresses UD's needs. Recent applied UD tutorial: Oron et al., 2022 . Recent methodological overview: Oron and Flournoy, 2024 .