Functions for Kernel-Regularized Least Squares optimized for speed and memory usage are provided along with visualization tools. For working papers, sample code, and recent presentations visit < https://sites.google.com/site/petemohanty/software/>. bigKRLS, as well its dependencies, require current versions of R and its compilers (and RStudio if used). For details, see < https://github.com/rdrr1990/bigKRLS/blob/master/INSTALL.md>.