Dose Transition Pathways for Time-to-Event Dose-Finding Designs

Implements the Dose Transition Pathways (DTP) look-ahead strategy for time-to-event phase I dose-finding clinical trials with delayed or pending toxicity outcomes. Provides a DTP decorator for the 'escalation' framework, supporting both TITE-CRM (model-based) and TITE-BOIN (model-assisted) base designs.


Reference manual

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install.packages("dtptite")

0.1.0 by Xiaoran Lai, 12 hours ago


https://github.com/ICR-EPAT/dtptite


Report a bug at https://github.com/ICR-EPAT/dtptite/issues


Browse source code at https://github.com/cran/dtptite


Authors: Xiaoran Lai [aut, cre] , The Institute of Cancer Research [cph] , National Institute for Health and Care Research [fnd]


Documentation:   PDF Manual  


GPL (>= 3) license


Imports BOIN, dplyr, escalation, stats, tibble

Suggests dfcrm, ggplot2, testthat, TITEgBOIN


See at CRAN