Genome-Wide Association Study with SLOPE

Genome-wide association study (GWAS) performed with SLOPE, short for Sorted L-One Penalized Estimation, a method for estimating the vector of coefficients in linear model. In the first step of GWAS, SNPs are clumped according to their correlations and distances. Then, SLOPE is performed on data where each clump has one representative.


Reference manual

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0.37.0 by Piotr Sobczyk, 2 years ago

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Browse source code at

Authors: Damian Brzyski [aut], Christine Peterson [aut], Emmanuel J. Candes [aut], Malgorzata Bogdan [aut], Chiara Sabatti [aut], Piotr Sobczyk [cre, aut]

Documentation:   PDF Manual  

GPL-3 license

Imports ggplot2, bigmemory, grid, utils, stats

Depends on SLOPE

Suggests shiny, knitr, rmarkdown, testthat

See at CRAN