Noncompartmental Pharmacokinetic Analysis by qPharmetra

Computes noncompartmental pharmacokinetic parameters for drug concentration profiles. For each profile, data imputations and adjustments are made as necessary and basic parameters are estimated. Supports single dose, multi-dose, and multi-subject data. Supports steady-state calculations and various routes of drug administration. See ?qpNCA and vignettes. Methodology follows Rowland and Tozer (2011, ISBN:978-0-683-07404-8), Gabrielsson and Weiner (1997, ISBN:978-91-9765-100-4), and Gibaldi and Perrier (1982, ISBN:978-0824710422).

qpNCA

Overview

qpNCA is qPharmetra’s R package for Noncompartmental Analysis. It provides regulatory-quality calculations of NCA parameters, using code routinely tested against independently-validated output. You can find appropriate manuals in the vignettes directory, and you can find tests and reference data in the tests directory.

Installation

The easiest way to get qpNCA is to install from CRAN:

install.packages("qpNCA")

Alternatively, install from github:

devtools::install_github('qpharmetra/qpNCA')

You can use the issues feature on github to report issues.

Usage

A good place to start is the help for qpNCA().

library(qpNCA)
?qpNCA
example(qpNCA)

Or see the vignettes, like this one for example.