Semiparametric Efficient Estimation for a Two-Sample Treatment Effect

Performs estimation and testing of the treatment effect in a 2-group randomized clinical trial with a quantitative, dichotomous, or right-censored time-to-event endpoint. The method improves efficiency by leveraging baseline predictors of the endpoint. The inverse probability weighting technique of Robins, Rotnitzky, and Zhao (JASA, 1994) is used to provide unbiased estimation when the endpoint is missing at random.


speff2trial

Reference manual

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install.packages("speff2trial")

1.0.5 by Michal Juraska, 4 years ago


https://github.com/mjuraska/speff2trial


Report a bug at https://github.com/mjuraska/speff2trial/issues


Browse source code at https://github.com/cran/speff2trial


Authors: Michal Juraska <[email protected]> , with contributions from Peter B. Gilbert <[email protected]> , Xiaomin Lu <[email protected]> , Min Zhang <[email protected]> , Marie Davidian <[email protected]> , and Anastasios A. Tsiatis <[email protected]>


Documentation:   PDF Manual  


GPL-2 license


Depends on stats, leaps, survival


Suggested by RobinCar2, dScoreTest.


See at CRAN