Biochemically Intuitive Generalized Loewe Model

Response surface methods for drug synergy analysis. Available methods include generalized and classical Loewe formulations as well as Highest Single Agent methodology. Response surfaces can be plotted in an interactive 3-D plot and formal statistical tests for presence of synergistic effects are available. Implemented methods and tests are described in the article "BIGL: Biochemically Intuitive Generalized Loewe null model for prediction of the expected combined effect compatible with partial agonism and antagonism" by Koen Van der Borght, Annelies Tourny, Rytis Bagdziunas, Olivier Thas, Maxim Nazarov, Heather Turner, Bie Verbist & Hugo Ceulemans (2017) .


1.3.0 (2019-02-28) o added Bliss independence null model 1.2.3 (2018-11-21) o better support for flat monotherapies 1.2.2 (2018-09-07) o make sure if no replicates are there model/unequal method is not allowed 1.2.1 (2018-08-24) o fix regression bug to allow custom axis labels for the contour plot 1.2.0 (2018-06-13) o support heterogeneous variance with new argument 'method' for 'fitSurface' 1.1.3 (2018-05-14) o show EC50 in log10 terms for monotherapy summary o allow custom compound names for plotting 1.1.2 (2018-05-07) o fix monotherapy formula in the vignette 1.1.1 (2018-01-02) o added reference to the original article o fix DESCRIPTION file according to new R CMD check policy 1.1.0 (2017-09-22) o isobologram() plot is now available for ResponseSurface objects It is also now included in the shiny app. o summary.ResponseSurface does not fail if marginal fits have constraints o Change of package maintainer 1.0.3 (2017-08-18) o Contour plot for maxR now has correct p-value labels o Summary for marginal fits does not fail if Hessian computation failed 1.0.2 (2017-07-31) o extra arguments in fitMarginals are now passed to the optimizer functions 1.0.1 (2017-06-29) o predict method added for the MarginalFit objects 1.0 (2017-06-28) o Initial public release

Reference manual

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1.6.4 by Maxim Nazarov, 22 days ago

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Authors: Heather Turner , Annelies Tourny , Olivier Thas , Maxim Nazarov , Rytis Bagdziunas , Stijn Hawinkel

Documentation:   PDF Manual  

GPL-3 license

Imports ggplot2, MASS, methods, minpack.lm, numDeriv, parallel, progress, rgl, robustbase, scales, nleqslv

Suggests knitr, rmarkdown, testthat, shiny, DT

See at CRAN