Given the hypothesis of a bimodal distribution of cells for each marker, the algorithm constructs a binary tree, the nodes of which are subpopulations of cells. At each node, observed cells and markers are modeled by both a family of normal distributions and a family of bimodal normal mixture distributions. Splitting is done according to a normalized difference of AIC between the two families.
cytometree is a package which performs automatic gating and annotation of flow-cytometry data. On top of the CRAN help files, we also provide a vignette illustrating the functionnalities of
The following article explains what
cytometree is about:
The easiest way to get
cytometree is to install it from CRAN:
Or to get the development version from GitHub:
-- Chariff Alkhassim & Boris Hejblum
NEWS.mdfile to track changes to the package.