Fused Sparse Structural Equation Models to Jointly Infer Gene Regulatory Network

An optimizer of Fused-Sparse Structural Equation Models, which is the state of the art jointly fused sparse maximum likelihood function for structural equation models proposed by Xin Zhou and Xiaodong Cai (2018 ).


fssemR

CRAN status CRAN download

fssemR is a package that ultilizes the Proximal Alternating Linearized Maximal to solve the non-convex non-smooth jointly fused sparse structrual equation model.

Installation

fssemR package contains a lot of necessary scripts to analyze large dataset such as microarray and SNP data from GEO database, so it has not been submitted to CRAN yet for these non-standard directory. To install fssemR, you need a C++ compiler such as g++ or clang++ with C++11 feature, and for Windows users, the Rtools software is needed (unless you can configure the toolchain by yourself).

The installation follows the typical way of R packages on Github:

library(devtools)
install_github("Ivis4ml/fssemR")

Now, fssemR package is uploaded on CRAN. So you will install it via CRAN

install.packages("fssemR")

Vignette

fssemR-introduction

Citation

Xin Zhou, Xiaodong Cai, Inference of differential gene regulatory networks based on gene expression and genetic perturbation data, Bioinformatics, , btz529, https://doi.org/10.1093/bioinformatics/btz529

Update

Upgrade to Eigen 0.3.4 compatible

Reference manual

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install.packages("fssemR")

0.1.8 by Xin Zhou, 5 years ago


https://github.com/Ivis4ml/fssemR


Browse source code at https://github.com/cran/fssemR


Authors: Xin Zhou , Xiaodong Cai


Documentation:   PDF Manual  


GPL (>= 3) license


Imports Rcpp, Matrix, stats, igraph, mvtnorm, qtl, stringr, glmnet, MASS, qpdf

Depends on methods

Suggests plotly, knitr, rmarkdown, network, ggnetwork

Linking to Rcpp, RcppEigen


See at CRAN