Decipher Mutational Signatures from Somatic Mutational Catalogs

Cancer cells accumulate DNA mutations as result of DNA damage and DNA repair processes. This computational framework is aimed at deciphering DNA mutational signatures operating in cancer. The input is a numeric matrix of DNA mutation counts detected in a panel of cancer samples. The framework performs Non-negative Matrix Factorization to extract the most likely signatures explaining the observed set of DNA mutations. The framework relies on parallelization and is optimized for use on multi-core systems. This framework is an R-based implementation of the original MATLAB WTSI framework by Alexandrov LB et al (2013) .


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install.packages("mutSignatures")

1.2 by Damiano Fantini, 10 months ago


Browse source code at https://github.com/cran/mutSignatures


Authors: Damiano Fantini, Joshua J Meeks


Documentation:   PDF Manual  


GPL-2 license


Imports cluster, pracma, proxy

Depends on doParallel, ggplot2, foreach


See at CRAN