Nonlinear Mixed Effects Models in Population PK/PD, Data

Datasets for 'nlmixr2' and 'rxode2'. 'nlmixr2' is used for fitting and comparing nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 ). Differential equation solving is by compiled C code provided in the 'rxode2' package (Wang, Hallow, and James 2015 ).

Functions for Timing R Scripts, as Well as Implementations of "Stack" and "StackList" Structures

Code execution timing functions 'tic' and 'toc' that can be nested. One can record all timings while a complex script is running, and examine the values later. It is also possible to instrument the timing calls with custom callbacks. In addition, this package provides class 'Stack', implemented as a vector, and class 'StackList', which is a stack implemented as a list, both of which support operations 'push', 'pop', 'first_element', 'last_element' and 'clear'.

Image Processing Library Based on 'CImg'

Fast image processing for images in up to 4 dimensions (two spatial dimensions, one time/depth dimension, one colour dimension). Provides most traditional image processing tools (filtering, morphology, transformations, etc.) as well as various functions for easily analysing image data using R. The package wraps 'CImg', < https://cimg.eu>, a simple, modern C++ library for image processing.

Wrapper for 'lz-string' 'C++' Library

Provide access to the 'lz-string' < http://pieroxy.net/blog/pages/lz-string/index.html> 'C++' library for Lempel-Ziv (LZ) based compression and decompression of strings.

Random Sampling Distribution C++ Routines for Armadillo

Provides popular sampling distributions C++ routines based in armadillo through a header file approach.

Rmetrics - Chronological and Calendar Objects

The 'timeDate' class fulfils the conventions of the ISO 8601 standard as well as of the ANSI C and POSIX standards. Beyond these standards it provides the "Financial Center" concept which allows to handle data records collected in different time zones and mix them up to have always the proper time stamps with respect to your personal financial center, or alternatively to the GMT reference time. It can thus also handle time stamps from historical data records from the same time zone, even if the financial centers changed day light saving times at different calendar dates.

'C++' Headers for 'ggdmc' Package

A fast 'C++' implementation of the design-based, Diffusion Decision Model (DDM) and the Linear Ballistic Accumulation (LBA) model. It enables the user to optimise the choice response time model by connecting with the Differential Evolution Markov Chain Monte Carlo (DE-MCMC) sampler implemented in the 'ggdmc' package. The package fuses the hierarchical modelling, Bayesian inference, choice response time models and factorial designs, allowing users to build their own design-based models. For more information on the underlying models, see the works by Voss, Rothermund, and Voss (2004) , Ratcliff and McKoon (2008) , and Brown and Heathcote (2008) .

C-Statistics for Risk Prediction Models with Censored Survival Data

Performs inference for C of risk prediction models with censored survival data, using the method proposed by Uno et al. (2011) . Inference for the difference in C between two competing prediction models is also implemented.

Ensemble Empirical Mode Decomposition (EEMD) and Its Complete Variant (CEEMDAN)

An R interface for libeemd (Luukko, Helske, Räsänen, 2016) , a C library of highly efficient parallelizable functions for performing the ensemble empirical mode decomposition (EEMD), its complete variant (CEEMDAN), the regular empirical mode decomposition (EMD), and bivariate EMD (BEMD). Due to the possible portability issues CRAN version no longer supports OpenMP, but you can install OpenMP-supported version from GitHub: < https://github.com/helske/Rlibeemd/>.

MCMC, Particle Filtering, and Programmable Hierarchical Modeling

A system for writing hierarchical statistical models largely compatible with 'BUGS' and 'JAGS', writing nimbleFunctions to operate models and do basic R-style math, and compiling both models and nimbleFunctions via custom-generated C++. 'NIMBLE' includes default methods for MCMC, Laplace Approximation, deterministic nested approximations, Monte Carlo Expectation Maximization, and some other tools. The nimbleFunction system makes it easy to do things like implement new MCMC samplers from R, customize the assignment of samplers to different parts of a model from R, and compile the new samplers automatically via C++ alongside the samplers 'NIMBLE' provides. 'NIMBLE' extends the 'BUGS'/'JAGS' language by making it extensible: New distributions and functions can be added, including as calls to external compiled code. Although most people think of MCMC as the main goal of the 'BUGS'/'JAGS' language for writing models, one can use 'NIMBLE' for writing arbitrary other kinds of model-generic algorithms as well. A full User Manual is available at < https://r-nimble.org>.