Outlier Detection Using Invariant Coordinate Selection

Multivariate outlier detection is performed using invariant coordinates where the package offers different methods to choose the appropriate components. ICS is a general multivariate technique with many applications in multivariate analysis. ICSOutlier offers a selection of functions for automated detection of outliers in the data based on a fitted ICS object or by specifying the dataset and the scatters of interest. The current implementation targets data sets with only a small percentage of outliers.

Nonlinear Mixed Effects Models in Population PK/PD

Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 ). Differential equation solving is by compiled C code provided in the 'rxode2' package (Wang, Hallow, and James 2015 ).

Interpolation and Extrapolation for Species Diversity

Provides simple functions to compute and plot two types (sample-size- and coverage-based) rarefaction and extrapolation curves for species diversity (Hill numbers) based on individual-based abundance data or sampling-unit- based incidence data; see Chao and others (2014, Ecological Monographs) for pertinent theory and methodologies, and Hsieh, Ma and Chao (2016, Methods in Ecology and Evolution) for an introduction of the R package.

Functional Data Analysis and Empirical Dynamics

A versatile package that provides implementation of various methods of Functional Data Analysis (FDA) and Empirical Dynamics. The core of this package is Functional Principal Component Analysis (FPCA), a key technique for functional data analysis, for sparsely or densely sampled random trajectories and time courses, via the Principal Analysis by Conditional Estimation (PACE) algorithm. This core algorithm yields covariance and mean functions, eigenfunctions and principal component (scores), for both functional data and derivatives, for both dense (functional) and sparse (longitudinal) sampling designs. For sparse designs, it provides fitted continuous trajectories with confidence bands, even for subjects with very few longitudinal observations. PACE is a viable and flexible alternative to random effects modeling of longitudinal data. There is also a Matlab version (PACE) that contains some methods not available on fdapace and vice versa. Updates to fdapace were supported by grants from NIH Echo and NSF DMS-1712864 and DMS-2014626. Please cite our package if you use it (You may run the command citation("fdapace") to get the citation format and bibtex entry). References: Wang, J.L., Chiou, J., Müller, H.G. (2016) ; Chen, K., Zhang, X., Petersen, A., Müller, H.G. (2017) .

Experiment-Selector CV-TMLE for Integration of Observational and RCT Data

The experiment selector cross-validated targeted maximum likelihood estimator (ES-CVTMLE) aims to select the experiment that optimizes the bias-variance tradeoff for estimating a causal average treatment effect (ATE) where different experiments may include a randomized controlled trial (RCT) alone or an RCT combined with real-world data. Using cross-validation, the ES-CVTMLE separates the selection of the optimal experiment from the estimation of the ATE for the chosen experiment. The estimated bias term in the selector is a function of the difference in conditional mean outcome under control for the RCT compared to the combined experiment. In order to help include truly unbiased external data in the analysis, the estimated average treatment effect on a negative control outcome may be added to the bias term in the selector. For more details about this method, please see Dang et al. (2022) .

Species-Richness Prediction and Diversity Estimation with R

Estimation of various biodiversity indices and related (dis)similarity measures based on individual-based (abundance) data or sampling-unit-based (incidence) data taken from one or multiple communities/assemblages.

A Statistical Methodology to Select Covariates in High-Dimensional Data under Dependence

Two steps variable selection procedure in a context of high-dimensional dependent data but few observations. First step is dedicated to eliminate dependence between variables (clustering of variables, followed by factor analysis inside each cluster). Second step is a variable selection using by aggregation of adapted methods. Bastien B., Chakir H., Gegout-Petit A., Muller-Gueudin A., Shi Y. A statistical methodology to select covariates in high-dimensional data under dependence. Application to the classification of genetic profiles associated with outcome of a non-small-cell lung cancer treatment. 2018. < https://hal.archives-ouvertes.fr/hal-01939694>.

Small Helpers and Tricks for Epidemics Analysis

A collection of small functions useful for epidemics analysis and infectious disease modelling. This includes computation of basic reproduction numbers from growth rates, generation of hashed labels to anonymize data, and fitting discretized Gamma distributions.

Chronological Bayesian Models Integrating Optically Stimulated Luminescence and Radiocarbon Age Dating

Bayesian analysis of luminescence data and C-14 age estimates. Bayesian models are based on the following publications: Combes, B. & Philippe, A. (2017) and Combes et al. (2015) . This includes, amongst others, data import, export, application of age models and palaeodose model.

Processing and Analysing Animal Trajectories

Tools to handle, manipulate and explore trajectory data, with an emphasis on data from tracked animals. The package is designed to support large studies with several million location records and keep track of units where possible. Data import directly from 'movebank' < https://www.movebank.org/cms/movebank-main> and files is facilitated.