Continuous Time Structural Equation Modelling - Old 'OpenMx'-Based Version

Original 'ctsem' (continuous time structural equation modelling) functionality, based on the 'OpenMx' software, as described in Driver, Oud, Voelkle (2017) , with updated details in vignette. Combines stochastic differential equations representing latent processes with structural equation measurement models. This package is maintained for consistency with the original 'ctsem' paper, but for the much newer and more capable 'ctsem' package, see < https://cran.r-project.org/package=ctsem>.

Wrapper Functions Around 'Charles Schwab Individual Trader API'

For those wishing to interact with the 'Charles Schwab Individual Trader API' (< https://developer.schwab.com/products/trader-api--individual>) with R in a simplified manner, this package offers wrapper functions around authentication and the available API calls to streamline the process.

Advanced 'tryCatch()' and 'try()' Functions

Advanced tryCatch() and try() functions for better error handling (logging, stack trace with source code references and support for post-mortem analysis via dump files).

Two Stage Hazard Rate Comparison

Two-stage procedure compares hazard rate functions, which may or may not cross each other.

k-Nearest Neighbor Join for Spatial Data

K-nearest neighbor search for projected and non-projected 'sf' spatial layers. Nearest neighbor search uses (1) C code from 'GeographicLib' for lon-lat point layers, (2) function knn() from package 'nabor' for projected point layers, or (3) function st_distance() from package 'sf' for line or polygon layers. The package also includes several other utility functions for spatial analysis.

Tools for Flexible Survival Analysis Using Machine Learning

Statistical tools for analyzing time-to-event data using machine learning. Implements survival stacking for conditional survival estimation, standardized survival function estimation for current status data, and methods for algorithm-agnostic variable importance. See Wolock CJ, Gilbert PB, Simon N, and Carone M (2024) .

Inference and Prediction of Generic Physiologically-Based Kinetic Models

Fit and simulate any kind of physiologically-based kinetic ('PBK') models whatever the number of compartments. Moreover, it allows to account for any link between pairs of compartments, as well as any link of each of the compartments with the external medium. Such generic PBK models have today applications in pharmacology (PBPK models) to describe drug effects, in toxicology and ecotoxicology (PBTK models) to describe chemical substance effects. In case of exposure to a parent compound (drug or chemical) the 'rPBK' package allows to consider metabolites, whatever their number and their phase (I, II, ...). Last but not least, package 'rPBK' can also be used for dynamic flux balance analysis (dFBA) to deal with metabolic networks. See also Charles et al. (2022) .

Bayesian Inference of TKTD Models

Advanced methods for a valuable quantitative environmental risk assessment using Bayesian inference of survival Data with toxicokinetics toxicodynamics (TKTD) models. Among others, it facilitates Bayesian inference of the general unified threshold model of survival (GUTS). See models description in Jager et al. (2011) and implementation using Bayesian inference in Baudrot and Charles (2019) .

Simulate from ODE-Based Models

Fast simulation from ordinary differential equation (ODE) based models typically employed in quantitative pharmacology and systems biology.

Extended Structural Equation Modelling

Create structural equation models that can be manipulated programmatically. Models may be specified with matrices or paths (LISREL or RAM) Example models include confirmatory factor, multiple group, mixture distribution, categorical threshold, modern test theory, differential Fit functions include full information maximum likelihood, maximum likelihood, and weighted least squares. equations, state space, and many others. Support and advanced package binaries available at < https://openmx.ssri.psu.edu>. The software is described in Neale, Hunter, Pritikin, Zahery, Brick, Kirkpatrick, Estabrook, Bates, Maes, & Boker (2016) .