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Omics Data Integration Using Kernel Methods

Kernel-based methods are powerful methods for integrating
heterogeneous types of data. mixKernel aims at providing methods to combine
kernel for unsupervised exploratory analysis. Different solutions are
provided to compute a meta-kernel, in a consensus way or in a way that
best preserves the original topology of the data. mixKernel also integrates
kernel PCA to visualize similarities between samples in a non linear space
and from the multiple source point of view. Functions to assess and display
important variables are also provided in the package. Ref: Jerome Mariette
and Nathalie Villa-Vialaneix (2018)

SOM Bound to Realize Euclidean and Relational Outputs

The stochastic (also called on-line) version of the Self-Organising
Map (SOM) algorithm is provided. Different versions of the
algorithm are implemented, for numeric and relational data and for
contingency tables as described, respectively, in Kohonen (2001)

Log-Linear Poisson Graphical Model with Hot-Deck Multiple Imputation

Infer log-linear Poisson Graphical Model with an auxiliary data
set. Hot-deck multiple imputation method is used to improve the reliability
of the inference with an auxiliary dataset. Standard log-linear Poisson
graphical model can also be used for the inference and the Stability
Approach for Regularization Selection (StARS) is implemented to drive the
selection of the regularization parameter. The method is fully described in

Sparse Interval Sliced Inverse Regression

An interval fusion procedure for functional data in the
semiparametric framework of SIR, as described in

Monazite Dating for the NiLeDAM Team

Th-U-Pb electron microprobe age dating of monazite, as originally
described in

Adjacency-Constrained Clustering of a Block-Diagonal Similarity Matrix

Implements a constrained version of hierarchical agglomerative clustering, in which each observation is associated to a position, and only adjacent clusters can be merged. Typical application fields in bioinformatics include Genome-Wide Association Studies or Hi-C data analysis, where the similarity between items is a decreasing function of their genomic distance. Taking advantage of this feature, the implemented algorithm is time and memory efficient. This algorithm is described in Ambroise et al (2019) < https://almob.biomedcentral.com/articles/10.1186/s13015-019-0157-4>.

Weighted Cox-Regression for Nested Case-Control Data

Fit Cox proportional hazard models with a weighted partial likelihood. It handles one or multiple endpoints, additional matching and makes it possible to reuse controls for other endpoints.

Inverse Probability of Censoring Weights to Deal with Treatment Switch in Randomized Clinical Trials

Contains functions for formatting clinical trials data and implementing inverse probability of censoring weights to handle treatment switches when estimating causal treatment effect in randomized clinical trials.

Estimate Migration Birds Flyways Network with HSMM

Estimate migration birds flyways network from counts with a Hidden Semi-Markov Model (HSMM). Implements several methods to estimate parameters: Monte Carlo Expectationâ€“Maximization (MCEM) and Approximate Bayesian Approach (ABC).

Inference About the Standardized Mortality Ratio when Evaluating the Effect of a Screening Program on Survival

Functions to make inference about the
standardized mortality ratio (SMR) when evaluating the
effect of a screening program. The package is
based on methods described in Sasieni (2003)