Simulate from ODE-Based Population PK/PD and Systems Pharmacology Models

Facilitates simulation from hierarchical, ordinary differential equation (ODE) based models typically employed in drug development. A model specification file is created consisting of R and C++ code that is parsed, compiled, and dynamically loaded into the R session. Input data are passed in and simulated data are returned as R objects. A dosing event engine allows interventions (bolus and infusion) to be managed separately from the model code. Differential equations are solved with the 'DLSODA' routine in 'ODEPACK' (< https://computation.llnl.gov/casc/odepack/>).


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install.packages("mrgsolve")

0.8.10 by Kyle T Baron, 24 days ago


https://github.com/metrumresearchgroup/mrgsolve


Report a bug at https://github.com/metrumresearchgroup/mrgsolve/issues


Browse source code at https://github.com/cran/mrgsolve


Authors: Kyle T Baron [aut, cre], Alan C Hindmarsh [ctb], Linda R Petzold [ctb], Bill Gillespie [ctb], Charles Margossian [ctb], Devin Pastoor [ctb], Metrum Research Group LLC [cph]


Documentation:   PDF Manual  


Task views: Analysis of Pharmacokinetic Data


GPL (>= 2) license


Imports Rcpp, dplyr, magrittr, lazyeval, RcppArmadillo, tibble

Depends on methods

Suggests lattice, testthat, XML, rmarkdown

Linking to Rcpp, RcppArmadillo, BH


See at CRAN