Pharmacometric and Pharmacokinetic Toolkit

Pharmacometric tools for common data analytical tasks; closed-form solutions for calculating concentrations at given times after dosing based on compartmental PK models (1-compartment, 2-compartment and 3-compartment, covering infusions, zero- and first-order absorption, and lag times, after single doses and at steady state, per Bertrand & Mentre (2008) <>); parametric simulation from NONMEM-generated parameter estimates and other output; and parsing, tabulating and plotting results generated by Perl-speaks-NONMEM (PsN).


Reference manual

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1.2.1 by Justin Wilkins, 8 months ago

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Browse source code at

Authors: Justin Wilkins [aut, cre] , Bill Denney [aut] , Rik Schoemaker [aut] , Leonid Gibiansky [ctb] , Andrew Hooker [ctb] , E. Niclas Jonsson [ctb] , Mats O. Karlsson [ctb] , John Johnson [ctb]

Documentation:   PDF Manual  

Task views: Analysis of Pharmacokinetic Data

GPL-2 license

Imports ggplot2, ggrepel, gridExtra, chron, xml2, dplyr

Depends on MASS, stringr, magrittr, data.tree, DiagrammeR

Suggests testthat, knitr, rmarkdown

Suggested by mrgsolve.

See at CRAN