Nonlinear Mixed Effects Models in Population PK/PD, Data

Datasets for 'nlmixr2' and 'rxode2'. 'nlmixr2' is used for fitting and comparing nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 ). Differential equation solving is by compiled C code provided in the 'rxode2' package (Wang, Hallow, and James 2015 ).

Bayesian Profile Regression using Generalised Linear Mixed Models

Implements a Bayesian profile regression using a generalized linear mixed model as output model. The package allows for binary (probit mixed model) and continuous (linear mixed model) outcomes and both continuous and categorical clustering variables. The package utilizes 'RcppArmadillo' and 'RcppDist' for high-performance statistical computing in C++. For more details see Amestoy & al. (2025) .

Generalized Additive Mixed Model Analysis via Slice Sampling

Uses a slice sampling-based Markov chain Monte Carlo to conduct Bayesian fitting and inference for generalized additive mixed models. Generalized linear mixed models and generalized additive models are also handled as special cases of generalized additive mixed models. The methodology and software is described in Pham, T.H. and Wand, M.P. (2018). Australian and New Zealand Journal of Statistics, 60, 279-330 .

Generalized Linear Mixed Model Analysis via Expectation Propagation

Approximate frequentist inference for generalized linear mixed model analysis with expectation propagation used to circumvent the need for multivariate integration. In this version, the random effects can be any reasonable dimension. However, only probit mixed models with one level of nesting are supported. The methodology is described in Hall, Johnstone, Ormerod, Wand and Yu (2018) .

Isoscape Computation and Inference of Spatial Origins using Mixed Models

Building isoscapes using mixed models and inferring the geographic origin of samples based on their isotopic ratios. This package is essentially a simplified interface to several other packages which implements a new statistical framework based on mixed models. It uses 'spaMM' for fitting and predicting isoscapes, and assigning an organism's origin depending on its isotopic ratio. 'IsoriX' also relies heavily on the package 'rasterVis' for plotting the maps produced with 'terra' using 'lattice'.

General Linear Mixed Models for Gene-Level Differential Expression

Using mixed effects models to analyse longitudinal gene expression can highlight differences between sample groups over time. The most widely used differential gene expression tools are unable to fit linear mixed effect models, and are less optimal for analysing longitudinal data. This package provides negative binomial and Gaussian mixed effects models to fit gene expression and other biological data across repeated samples. This is particularly useful for investigating changes in RNA-Sequencing gene expression between groups of individuals over time, as described in: Rivellese, F., Surace, A. E., Goldmann, K., Sciacca, E., Cubuk, C., Giorli, G., ... Lewis, M. J., & Pitzalis, C. (2022) Nature medicine .

A Fast Laplace Method for Spatial Generalized Linear Mixed Model

Fitting a fast Laplace approximation for Spatial Generalized Linear Mixed Model as described in Park and Lee (2021) < https://github.com/sangwan93/fastLaplace/blob/main/FastLaplaceMain.pdf>.

Fitting Linear Quantile Regression Mixed Models with Relationship Matrix

Fit a quantile regression mixed model involved Relationship Matrix using a sparse implementation of the Frisch-Newton interior-point algorithm as described in Portnoy and Koenker (1977, Statistical Science) < https://www.jstor.org/stable/2246216>.

Fast Functional Mixed Models using Fast Univariate Inference

Implementation of the fast univariate inference approach (Cui et al. (2022) , Loewinger et al. (2024) , Xin et al. (2025)) for fitting functional mixed models. User guides and Python package information can be found at < https://github.com/gloewing/photometry_FLMM>.

High Dimensional Penalized Generalized Linear Mixed Models (pGLMM)

Fits high dimensional penalized generalized linear mixed models using the Monte Carlo Expectation Conditional Minimization (MCECM) algorithm. The purpose of the package is to perform variable selection on both the fixed and random effects simultaneously for generalized linear mixed models. The package supports fitting of Binomial, Gaussian, and Poisson data with canonical links, and supports penalization using the MCP, SCAD, or LASSO penalties. The MCECM algorithm is described in Rashid et al. (2020) . The techniques used in the minimization portion of the procedure (the M-step) are derived from the procedures of the 'ncvreg' package (Breheny and Huang (2011) ) and 'grpreg' package (Breheny and Huang (2015) ), with appropriate modifications to account for the estimation and penalization of the random effects. The 'ncvreg' and 'grpreg' packages also describe the MCP, SCAD, and LASSO penalties.