Automated and Early Detection of Disease Outbreaks

A powerful tool for automating the early detection of disease outbreaks in time series data. 'aeddo' employs advanced statistical methods, including hierarchical models, in an innovative manner to effectively characterize outbreak signals. It is particularly useful for epidemiologists, public health professionals, and researchers seeking to identify and respond to disease outbreaks in a timely fashion. For a detailed reference on hierarchical models, consult Henrik Madsen and Poul Thyregod's book (2011), ISBN: 9781420091557.

Fitting (Exponential/Diffusion) RT-MPT Models

Fit (exponential or diffusion) response-time extended multinomial processing tree (RT-MPT) models by Klauer and Kellen (2018) and Klauer, Hartmann, and Meyer-Grant (submitted). The RT-MPT class not only incorporate frequencies like traditional multinomial processing tree (MPT) models, but also latencies. This enables it to estimate process completion times and encoding plus motor execution times next to the process probabilities of traditional MPTs. 'rtmpt' is a hierarchical Bayesian framework and posterior samples are sampled using a Metropolis-within-Gibbs sampler (for exponential RT-MPTs) or Hamiltonian-within-Gibbs sampler (for diffusion RT-MPTs).

Multi-Patient Analysis of Genomic Markers

Preprocessing and analysis of genomic data. 'MPAgenomics' provides wrappers from commonly used packages to streamline their repeated manipulation, offering an easy-to-use pipeline. The segmentation of successive multiple profiles is performed with an automatic choice of parameters involved in the wrapped packages. Considering multiple profiles in the same time, 'MPAgenomics' wraps efficient penalized regression methods to select relevant markers associated with a given outcome. Grimonprez et al. (2014) .

Dynamic Models for Confidence and Response Time Distributions

Provides density functions for the joint distribution of choice, response time and confidence for discrete confidence judgments as well as functions for parameter fitting, prediction and simulation for various dynamical models of decision confidence. All models are explained in detail by Hellmann et al. (2023; Preprint available at < https://osf.io/9jfqr/>, published version: ). Implemented models are the dynaViTE model, dynWEV model, the 2DSD model (Pleskac & Busemeyer, 2010, ), and various race models. C++ code for dynWEV and 2DSD is based on the 'rtdists' package by Henrik Singmann.

Estimated Marginal Means, aka Least-Squares Means

Obtain estimated marginal means (EMMs) for many linear, generalized linear, and mixed models. Compute contrasts or linear functions of EMMs, trends, and comparisons of slopes. Plots and other displays. Least-squares means are discussed, and the term "estimated marginal means" is suggested, in Searle, Speed, and Milliken (1980) Population marginal means in the linear model: An alternative to least squares means, The American Statistician 34(4), 216-221 .

Complete Functional Regulation Analysis

Calculates complete functional regulation analysis and visualize the results in a single heatmap. The provided example data is for biological data but the methodology can be used for large data sets to compare quantitative entities that can be grouped. For example, a store might divide entities into cloth, food, car products etc and want to see how sales changes in the groups after some event. The theoretical background for the calculations are provided in New insights into functional regulation in MS-based drug profiling, Ana Sofia Carvalho, Henrik Molina & Rune Matthiesen, Scientific Reports .

Item Selection and Exhaustive Search for Rasch Models

Automation of the item selection processes for Rasch scales by means of exhaustive search for suitable Rasch models (dichotomous, partial credit, rating-scale) in a list of item-combinations. The item-combinations to test can be either all possible combinations or item-combinations can be defined by several rules (forced inclusion of specific items, exclusion of combinations, minimum/maximum items of a subset of items). Tests for model fit and item fit include ordering of the thresholds, item fit-indices, likelihood ratio test, Martin-Löf test, Wald-like test, person-item distribution, person separation index, principal components of Rasch residuals, empirical representation of all raw scores or Rasch trees for detecting differential item functioning. The tests, their ordering and their parameters can be defined by the user. For parameter estimation and model tests, functions of the packages 'eRm', 'psychotools' or 'pairwise' can be used.

Tidy Population Genetics

We provide a tidy grammar of population genetics, facilitating the manipulation and analysis of data on biallelic single nucleotide polymorphisms (SNPs). 'tidypopgen' scales to very large genetic datasets by storing genotypes on disk, and performing operations on them in chunks, without ever loading all data in memory. The full functionalities of the package are described in Carter et al. (2025) .

Bridge Sampling for Marginal Likelihoods and Bayes Factors

Provides functions for estimating marginal likelihoods, Bayes factors, posterior model probabilities, and normalizing constants in general, via different versions of bridge sampling (Meng & Wong, 1996, < https://www3.stat.sinica.edu.tw/statistica/j6n4/j6n43/j6n43.htm>). Gronau, Singmann, & Wagenmakers (2020) .

R Bindings for Calling the 'Earth Engine' API

Earth Engine < https://earthengine.google.com/> client library for R. All of the 'Earth Engine' API classes, modules, and functions are made available. Additional functions implemented include importing (exporting) of Earth Engine spatial objects, extraction of time series, interactive map display, assets management interface, and metadata display. See < https://r-spatial.github.io/rgee/> for further details.