Evaluation of Surrogate Endpoints in Clinical Trials

In a clinical trial, it frequently occurs that the most credible outcome to evaluate the effectiveness of a new therapy (the true endpoint) is difficult to measure. In such a situation, it can be an effective strategy to replace the true endpoint by a (bio)marker that is easier to measure and that allows for a prediction of the treatment effect on the true endpoint (a surrogate endpoint). The package 'Surrogate' allows for an evaluation of the appropriateness of a candidate surrogate endpoint based on the meta-analytic, information-theoretic, and causal-inference frameworks. Part of this software has been developed using funding provided from the European Union's Seventh Framework Programme for research, technological development and demonstration under Grant Agreement no 602552.


Changes in version 0.2 - 1.1 o Added functions PPE.BinBin, comb27.BinBin, ECT, SPF.BinCont, Bootstrap.MEP.BinBin, PROC.BinBin, plot.PPE.BinBin.R o Dataset CIGTS_BinCont added

Changes in version 0.1.80 o ICA.ContCont.MultS, ICA.ContCont.MultS_alt and AA.Mult added o Typo corrected in Pred.TrialT.ContCont() function (thanks to Maria C. for reporting the typo)

Changes in version 0.1.73 - 0.1.79 o Fano.BinBin added o Changes in the function MarginalProbs, summary() has been added for object of class FixedDiscrDiscrIT o Typos corrected in manual o Option Histograms.Counterfactuals added in function CausalDiagramContCont() o Option Histograms.Correlations added in function CausalDiagramBinBin() o The function MaxEntContCont was added

Changes in version 0.1.72 o The function ICA.BinCont has been added

Changes in version 0.1-68 - 0.1-71

o The functions FixedDiscDiscrIT, ICA.BinBin.Grid.Sample.Uncert and Plot.FixedDiscrDiscrIT have been added o Corrected typos

Changes in version 0.1-65-0.1-67

o The functions MaxEntICABinBin and MaxEntSPFBinBin have been added o Corrected typos

Changes in version 0.1-64

o Corrected typos, changes in function TrialLevelMA

Changes in version 0.1-63

o Corrected typos, functions Prentice, TrialLevelIT, SurvSurvIT, FixedBinBinIT, FixedContBinIT, FixedBinContIT, and PredTrialTContCont added

Changes in version 0.1-62

o Corrected typos, updated namespace, functions TrialLevelContCont and TwoStageSurvSurv added

Changes in version: Surrogate_0.1-6

o The function Test.Mono has been added o Changes in plot and summary functions of ICA.BinBin, ICA.BinBin.Grid.Full, and ICA.BinBin.Grid.Sample

Changes in version: Surrogate_0.1-5

o The functions SPP.BinBin, ICA.Sample.ContCont, and ICA.BinBin.CounterAssum have been added

Changes in version: Surrogate_0.1-4

o The functions CausalDiagramBinBin, Restrictions.BinBin, ICA.BinBin.Grid.Full, and ICA.BinBin.Grid.Sample have been added

Changes in version: Surrogate_0.1-3

o Corrected typos

Changes in version: Surrogate_0.1-2

o The functions ICA.BinBin, MarginalProbs, RandVec, Sim.Data.CounterfactualsBinBin, and Sim.Data.CounterfactualsBinBin have been added

Changes in version: Surrogate_0.1-1

o The function CausalDiagramContCont has been added

o corrected some typos in .Rd files.

Reference manual

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1.2 by Wim Van der Elst, 3 months ago

Browse source code at https://github.com/cran/Surrogate

Authors: Wim Van der Elst , Paul Meyvisch , Alvaro Florez Poveda , Ariel Alonso , Hannah M. Ensor , Christopher J. Weir & Geert Molenberghs

Documentation:   PDF Manual  

GPL (>= 2) license

Imports rgl, lattice, latticeExtra, survival, nlme, lme4, OrdinalLogisticBiplot, logistf, rms, mixtools, parallel, ks, rootSolve, extraDistr

Depends on MASS, msm

See at CRAN