PKPD, PBPK, and Systems Pharmacology Modeling Tools

Complete work flow for the analysis of pharmacokinetic pharmacodynamic (PKPD), physiologically-based pharmacokinetic (PBPK) and systems pharmacology models including: creation of ordinary differential equation-based models, pooled parameter estimation, individual/population based simulations, rule-based simulations for clinical trial design and modeling assays, deployment with a customizable 'Shiny' app, and non-compartmental analysis. System-specific analysis templates can be generated and each element includes integrated reporting with 'PowerPoint' and 'Word'.


Reference manual

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1.0.5 by John Harrold, 14 days ago

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Browse source code at

Authors: John Harrold [aut, cre]

Documentation:   PDF Manual  

BSD_2_clause + file LICENSE license

Imports deSolve, dplyr, digest, doParallel, flextable, foreach, gridExtra, grid, ggplot2, knitr, magrittr, MASS, officer, optimx, PKNCA, pso, readxl, rmarkdown, rhandsontable, rstudioapi, scales, stats, stringr, shiny

Suggests GA, GGally, gridGraphics, webshot, testthat, ggrepel

System requirements: Perl

See at CRAN