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Improved Allele-Specific Copy Number of SNP Microarrays for Downstream Segmentation
The CalMaTe method calibrates preprocessed allele-specific copy number estimates (ASCNs) from DNA microarrays by controlling for single-nucleotide polymorphism-specific allelic crosstalk. The resulting ASCNs are on average more accurate, which increases the power of segmentation methods for detecting changes between copy number states in tumor studies including copy neutral loss of heterozygosity. CalMaTe applies to any ASCNs regardless of preprocessing method and microarray technology, e.g. Affymetrix and Illumina.
Analysis of Large Affymetrix Microarray Data Sets
A cross-platform R framework that facilitates processing of any number of Affymetrix microarray samples regardless of computer system. The only parameter that limits the number of chips that can be processed is the amount of available disk space. The Aroma Framework has successfully been used in studies to process tens of thousands of arrays. This package has actively been used since 2006.
An Efficient and Deterministic Method for Identifying Topological Domains in Genomes
The 'TopDom' method identifies topological domains in genomes from Hi-C sequence data (Shin et al., 2016
Convert Statistical Objects into Tidy Tibbles
Summarizes key information about statistical objects in tidy tibbles. This makes it easy to report results, create plots and consistently work with large numbers of models at once. Broom provides three verbs that each provide different types of information about a model. tidy() summarizes information about model components such as coefficients of a regression. glance() reports information about an entire model, such as goodness of fit measures like AIC and BIC. augment() adds information about individual observations to a dataset, such as fitted values or influence measures.
Sudoku Puzzle Generator and Solver
Generates, plays, and solves Sudoku puzzles. The GUI playSudoku() needs package "tkrplot" if you are not on Windows.
R Interface with Google Compute Engine
Interact with the 'Google Compute Engine' API in R. Lets you create, start and stop instances in the 'Google Cloud'. Support for preconfigured instances, with templates for common R needs.
Multi-Patient Analysis of Genomic Markers
Preprocessing and analysis of genomic data. 'MPAgenomics'
provides wrappers from commonly used packages to streamline their repeated
manipulation, offering an easy-to-use pipeline. The segmentation of
successive multiple profiles is performed with an automatic choice of
parameters involved in the wrapped packages. Considering multiple profiles
in the same time, 'MPAgenomics' wraps efficient penalized regression methods
to select relevant markers associated with a given outcome.
Grimonprez et al. (2014)
Tidy Population Genetics
We provide a tidy grammar of population genetics, facilitating
the manipulation and analysis of data on biallelic single nucleotide
polymorphisms (SNPs). 'tidypopgen' scales to very large genetic datasets
by storing genotypes on disk, and performing operations on them in
chunks, without ever loading all data in memory. The full
functionalities of the package are described in Carter et al. (2025)
R Bindings for Calling the 'Earth Engine' API
Earth Engine < https://earthengine.google.com/> client library for R. All of the 'Earth Engine' API classes, modules, and functions are made available. Additional functions implemented include importing (exporting) of Earth Engine spatial objects, extraction of time series, interactive map display, assets management interface, and metadata display. See < https://r-spatial.github.io/rgee/> for further details.
Complete Environment for Bayesian Inference
Provides a complete environment for Bayesian inference using a variety of different samplers (see ?LaplacesDemon for an overview).