Nonlinear Mixed Effects Models in Population PK/PD

Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 ). Differential equation solving is by compiled C code provided in the 'RxODE' package (Wang, Hallow, and James 2015 ).


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install.packages("nlmixr")

2.0.4 by Wenping Wang, 22 days ago


https://github.com/nlmixrdevelopment/nlmixr


Browse source code at https://github.com/cran/nlmixr


Authors: Matthew Fidler [aut] , Yuan Xiong [aut] , Rik Schoemaker [aut] , Justin Wilkins [aut] , Wenping Wang [aut, cre] , Robert Leary [ctb] , Mason McComb [aut] , Mirjam Trame [ctb] , Teun Post [ctb] , Richard Hooijmaijers [aut] , Hadley Wickham [ctb] , Dirk Eddelbuettel [cph] , Johannes Pfeifer [ctb] , Robert B. Schnabel [ctb] , Elizabeth Eskow [ctb] , Emmanuelle Comets [ctb] , Audrey Lavenu [ctb] , Marc Lavielle [ctb] , David Ardia [cph] , Daniel C. Dillon [ctb] , Katharine Mullen [cph] , Ben Goodrich [ctb]


Documentation:   PDF Manual  


Task views:


GPL (>= 2) license


Imports Rcpp, brew, parallel, lbfgsb3c, dparser, methods, ggplot2, rex, minqa, Matrix, n1qn1, fastGHQuad, RxODE, nlme, magrittr, backports, symengine

Suggests Deriv, Rvmmin, broom.mixed, crayon, knitr, data.table, devtools, digest, dotwhisker, dplyr, expm, flextable, ggtext, patchwork, gridExtra, huxtable, lattice, lbfgs, lotri, madness, matrixcalc, nloptr, officer, pkgdown, reshape2, rmarkdown, testthat, tidyr, ucminf, vpc, xgxr, yaml, xpose, generics, tibble, checkmate, cli, qs, covr, forecast, latticeExtra

Linking to dparser, RxODE, RcppEigen, lbfgsb3c, Rcpp, BH, StanHeaders, RcppArmadillo


Imported by xpose.nlmixr.

Suggested by ggPMX.


See at CRAN