Nonlinear Mixed Effects Models in Population PK/PD

Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 ). Differential equation solving is by compiled C code provided in the 'RxODE' package (Wang, Hallow, and James 2015 ).


Reference manual

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2.0.5 by Wenping Wang, 2 months ago

Browse source code at

Authors: Matthew Fidler [aut] , Yuan Xiong [aut] , Rik Schoemaker [aut] , Justin Wilkins [aut] , Wenping Wang [aut, cre] , Robert Leary [ctb] , Mason McComb [aut] , Vipul Mann [aut] , Mirjam Trame [ctb] , Teun Post [ctb] , Richard Hooijmaijers [aut] , Hadley Wickham [ctb] , Dirk Eddelbuettel [cph] , Johannes Pfeifer [ctb] , Robert B. Schnabel [ctb] , Elizabeth Eskow [ctb] , Emmanuelle Comets [ctb] , Audrey Lavenu [ctb] , Marc Lavielle [ctb] , David Ardia [cph] , Katharine Mullen [cph] , Ben Goodrich [ctb]

Documentation:   PDF Manual  

Task views: Differential Equations

GPL (>= 2) license

Imports Rcpp, brew, parallel, lbfgsb3c, dparser, methods, ggplot2, rex, minqa, Matrix, n1qn1, fastGHQuad, RxODE, nlme, magrittr, backports, symengine

Suggests Deriv, Rvmmin, broom.mixed, crayon, knitr, data.table, devtools, digest, dotwhisker, dplyr, expm, flextable, ggtext, patchwork, gridExtra, huxtable, lattice, lbfgs, lotri, madness, matrixcalc, nloptr, officer, pkgdown, reshape2, rmarkdown, testthat, tidyr, ucminf, vpc, xgxr, yaml, xpose, generics, tibble, checkmate, cli, qs, covr, forecast, latticeExtra

Linking to dparser, RxODE, RcppEigen, lbfgsb3c, Rcpp, BH, StanHeaders, RcppArmadillo

Imported by xpose.nlmixr.

Suggested by ggPMX.

See at CRAN