Highly Adaptive Lasso Conditional Density Estimation

An algorithm for flexible conditional density estimation based on application of pooled hazard regression to an artificial repeated measures dataset constructed by discretizing the support of the outcome variable. To facilitate flexible estimation of the conditional density, the highly adaptive lasso, a non-parametric regression function shown to estimate cadlag (RCLL) functions at a suitably fast convergence rate, is used. The use of pooled hazards regression for conditional density estimation as implemented here was first described for by Díaz and van der Laan (2011) . Building on the conditional density estimation utilities, non-parametric inverse probability weighted (IPW) estimators of the causal effects of additive modified treatment policies are implemented, using conditional density estimation to estimate the generalized propensity score. Non-parametric IPW estimators based on this can be coupled with undersmoothing of the generalized propensity score estimator to attain the semi-parametric efficiency bound (per Hejazi, Díaz, and van der Laan ).

Merged Block Randomization

Package to carry out merged block randomization (Van der Pas (2019), ), a restricted randomization method designed for small clinical trials (at most 100 subjects) or trials with small strata, for example in multicentre trials. It can be used for more than two groups or unequal randomization ratios.

Safe, Multiple, Simultaneous String Substitution

Designed to enable simultaneous substitution in strings in a safe fashion. Safe means it does not rely on placeholders (which can cause errors in same length matches).

Signal Processing

R implementation of the 'Octave' package 'signal', containing a variety of signal processing tools, such as signal generation and measurement, correlation and convolution, filtering, filter design, filter analysis and conversion, power spectrum analysis, system identification, decimation and sample rate change, and windowing.

Cross-Validated Area Under the ROC Curve Confidence Intervals

Tools for working with and evaluating cross-validated area under the ROC curve (AUC) estimators. The primary functions of the package are ci.cvAUC and ci.pooled.cvAUC, which report cross-validated AUC and compute confidence intervals for cross-validated AUC estimates based on influence curves for i.i.d. and pooled repeated measures data, respectively. One benefit to using influence curve based confidence intervals is that they require much less computation time than bootstrapping methods. The utility functions, AUC and cvAUC, are simple wrappers for functions from the ROCR package.

Classes for Relational Data

Tools to create and modify network objects. The network class can represent a range of relational data types, and supports arbitrary vertex/edge/graph attributes.

Extension of `data.frame`

Fast aggregation of large data (e.g. 100GB in RAM), fast ordered joins, fast add/modify/delete of columns by group using no copies at all, list columns, friendly and fast character-separated-value read/write. Offers a natural and flexible syntax, for faster development.

An Ensemble Method for Combining Subset-Specific Algorithm Fits

The Subsemble algorithm is a general subset ensemble prediction method, which can be used for small, moderate, or large datasets. Subsemble partitions the full dataset into subsets of observations, fits a specified underlying algorithm on each subset, and uses a unique form of k-fold cross-validation to output a prediction function that combines the subset-specific fits. An oracle result provides a theoretical performance guarantee for Subsemble. The paper, "Subsemble: An ensemble method for combining subset-specific algorithm fits" is authored by Stephanie Sapp, Mark J. van der Laan & John Canny (2014) .

Analyzing Data with Cellwise Outliers

Tools for detecting cellwise outliers and robust methods to analyze data which may contain them. Contains the implementation of the algorithms described in Rousseeuw and Van den Bossche (2018) (open access) Hubert et al. (2019) (open access), Raymaekers and Rousseeuw (2021) (open access), Raymaekers and Rousseeuw (2021) (open access), Raymaekers and Rousseeuw (2021) (open access), Raymaekers and Rousseeuw (2022) (open access) Rousseeuw (2022) (open access). Examples can be found in the vignettes: "DDC_examples", "MacroPCA_examples", "wrap_examples", "transfo_examples", "DI_examples", "cellMCD_examples" , "Correspondence_analysis_examples", and "cellwise_weights_examples".

Using CF-Compliant Calendars with Climate Projection Data

Support for all calendars as specified in the Climate and Forecast (CF) Metadata Conventions for climate and forecasting data. The CF Metadata Conventions is widely used for distributing files with climate observations or projections, including the Coupled Model Intercomparison Project (CMIP) data used by climate change scientists and the Intergovernmental Panel on Climate Change (IPCC). This package specifically allows the user to work with any of the CF-compliant calendars (many of which are not compliant with POSIXt). The CF time coordinate is formally defined in the CF Metadata Conventions document available at < https://cf-convention.github.io/Data/cf-conventions/cf-conventions-1.13/cf-conventions.html#time-coordinate>.