Adaptation of Virtual Twins Method from Jared Foster

Research of subgroups in random clinical trials with binary outcome and two treatments groups. This is an adaptation of the Jared Foster method (< https://www.ncbi.nlm.nih.gov/pubmed/21815180>).

A Procedure to Clean, Decompose and Aggregate Timeseries

Clean, decompose and aggregate univariate time series following the procedure "Cyclic/trend decomposition using bin interpolation" and the Logbox method for flagging outliers, both detailed in Ritter, F.: Technical note: A procedure to clean, decompose, and aggregate time series, Hydrol. Earth Syst. Sci., 27, 349–361, , 2023.

Keyword Assisted Topic Models

Fits keyword assisted topic models (keyATM) using collapsed Gibbs samplers. The keyATM combines the latent dirichlet allocation (LDA) models with a small number of keywords selected by researchers in order to improve the interpretability and topic classification of the LDA. The keyATM can also incorporate covariates and directly model time trends. The keyATM is proposed in Eshima, Imai, and Sasaki (2024) .

A DNA Reference Library Manager

Reference database manager offering a set of functions to import, organize, clean, filter, audit and export reference genetic data. Provide functions to download sequence data from Bold Systems (< https://www.boldsystems.org/>) and NCBI GenBank < https://www.ncbi.nlm.nih.gov/genbank/>. Designed as an environment for semi-automatic and assisted construction of reference databases and to improve standardization and repeatability in barcoding and metabarcoding studies.

A Toolbox for Manipulating Biological Sequences

Classes and functions to work with biological sequences (DNA, RNA and amino acid sequences). Implements S3 infrastructure to work with biological sequences as described in Keck (2020) . Provides a collection of functions to perform biological conversion among classes (transcription, translation) and basic operations on sequences (detection, selection and replacement based on positions or patterns). The package also provides functions to import and export sequences from and to other package formats.

Landscape Epidemiology and Evolution

A stochastic, spatially-explicit, demo-genetic model simulating the spread and evolution of a plant pathogen in a heterogeneous landscape to assess resistance deployment strategies. It is based on a spatial geometry for describing the landscape and allocation of different cultivars, a dispersal kernel for the dissemination of the pathogen, and a SEIR ('Susceptible-Exposed-Infectious-Removed’) structure with a discrete time step. It provides a useful tool to assess the performance of a wide range of deployment options with respect to their epidemiological, evolutionary and economic outcomes. Loup Rimbaud, Julien Papaïx, Jean-François Rey, Luke G Barrett, Peter H Thrall (2018) .

Latent Factor Mixed Models

Fast and accurate inference of gene-environment associations (GEA) in genome-wide studies (Caye et al., 2019, ). We developed a least-squares estimation approach for confounder and effect sizes estimation that provides a unique framework for several categories of genomic data, not restricted to genotypes. The speed of the new algorithm is several times faster than the existing GEA approaches, then our previous version of the 'LFMM' program present in the 'LEA' package (Frichot and Francois, 2015, ).

A Toolbox for Writing Pretty Papers and Reports

A toolbox for writing 'knitr', 'Sweave' or other 'LaTeX'- or 'markdown'-based reports and to prettify the output of various estimated models.

Visualize Data for Host and Viral Population from 'SMITIDstruct' using 'HTMLwidgets'

Visualisation tools for 'SMITIDstruct' package. Allow to visualize host timeline, transmission tree, index diversities and variant graph using 'HTMLwidgets'. It mainly using 'D3JS' javascript framework.

Sound Analysis and Synthesis

Functions for analysing, manipulating, displaying, editing and synthesizing time waves (particularly sound). This package processes time analysis (oscillograms and envelopes), spectral content, resonance quality factor, entropy, cross correlation and autocorrelation, zero-crossing, dominant frequency, analytic signal, frequency coherence, 2D and 3D spectrograms and many other analyses. See Sueur et al. (2008) and Sueur (2018) .